What is Megaderm®?
Megaderm has been developed to optimise the synergistic effects of Omega 6 and Omega 3. It is an Essential Fatty acid supplement for dogs and cats.
How does Megaderm differ from EFA –Z?
Megaderm is a more focused option to consider for managing pruritus. Megaderm contains a 5:1 ratio of Omega 6 to Omega 3. There is expert opinion supporting that this is the appropriate ratio. Much more Omega 3 is required than in EFA-Z to influence the inflammatory cascade. EFA-Z has a ratio of 40:1 Omega 6 to Omega 3 so it is more focused on keeping coat quality maintained and preventing seborrhoea.
How does Megaderm® influence inflammatory skin conditions?
Megaderm limits the outcome of the inflammatory processes by modifying EFA metabolism in the skin. This influences the metabolic pathways of Poly-unsaturated fatty acids (PUFAs) that are involved in the inflammatory cascade. Activity is achieved by depriving the inflammatory process of its initial substrate (the arachidonic acid, W 6), inhibiting its potential metabolic conversions, and diverting the metabolic pathways towards fatty acids that will produce anti-inflammatory (or less inflammatory) mediators instead of pro-inflammatory mediators.
Why use Omega 6 and Omega 3?
The synergistic effects of W 6 and W 3 EFAs are beneficial as well in restoring skin integrity and providing an anti-inflammatory effect, by the control of PUFAs metabolic pathways.
Omega 6 are well described for maintaining good coat quality by maintaining water balance and cell integrity, modifying cell proliferation, and maintaining lustre whilst minimising seborrhoea.
In contrast Omega 3 has limited specific coat quality activity but is a key influencer of the inflammatory cascade.